Indexat a

Llicència i ús

Citacions

Cited 167 times in

Cited 132 times in

Altmetrics

Grant support

This work was supported by the Boehringer Ingelheim and Eli Lilly and Co Diabetes Alliance. Boehringer Ingelheim was involved in the design and conduct of the study; collection, analysis, and interpretation of data; and preparation of this manuscript. Dr Marx received grant support from the German Research Foundation: SFB TRR 219 (projects M-03 and M-05).

Anàlisi d'autories institucional

Compartir

Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA

Publicat a:Circulation. 139 (3): 351-361 - 2019-01-15 139(3), DOI: 10.1161/CIRCULATIONAHA.118.038352

Autors: McGuire, Darren K; Alexander, John H; Johansen, Odd Erik; Perkovic, Vlado; Rosenstock, Julio; Cooper, Mark E; Wanner, Christoph; Kahn, Steven E; Toto, Robert D; Zinman, Bernard; Baanstra, David; Pfarr, Egon; Schnaidt, Sven; Meinicke, Thomas; George, Jyothis T; von Eynatten, Maximilian; Marx, Nikolaus; Aizenberg, D; Fiorella, A; Edgardo, N; Belen, C Ianina; Alonso, P; Walter, M; Maia, K; Guillermo, S; Leandro, B; Constanza, R M; Alejandra, N M; Melina, C; Ariel, I L; Martin, S; Rodrigo, C; Alvarez, C; Jorge, M Z; Gabriel, C; German, S; Bartolacci, I; Bolobanich, G A; Tale, T; Meritano, M; Echeverria, M G; Gerrini, S P; Alvarez, M R y; Torrijos, N; Berli, M; Coggiola, J; Castaneda, G; Rode, R; Milessi, R; Roude, A; Bono, J; Caresani, J; Arias, V; Westberg, J C; Allende, G; Liberman, A; Bordonava, A; Almagro, S M; Gerbaudo, C; Schiavi, L B; Budassi, N; Cecilia, M; Buncuga, M; Carlos, S; Osvaldo, T; Mercedes, S; Agustina, V M M; Aljandro, M; Alberto, D; Fiorella, M; Cantero, M; Cariganano, M S; Anadon, P; Cartasegna, L; Gabriela, M; Fernanda, A M; Alberto, Re Matias; Chacon, C; Jazmin, F M M; Colombo, H; Coni, E; Mattausch, S E; Thomsenhall, K; della Torre, M; Morandini, M; Zanini, A; Berra, F Colombo; Margarita, H; Commendatore, V; Tedesco, J; Bolzan, P G; Cuneo, C; Narcisa, G; Caputi, V Fernandez; Pablo, S; Sandra, G; Pacora, F Ferre; Tinari, M B; Jure, H O; Parody, M L; Toranzo, A; Frechtel, G; Yohena, S; Lovecchio, S; Muller, C; Olivera, C; Breyaui, M Dib; Bianchi, G; Garcia, C; Luciana, V; Florencia, F M; Ruben, G D; Gelersztein, E; Rey, G R; Sanchez, C; Fornasari, L; Di Pierro, L; Giacomi, G; Miguel, S; Laura, T; Gonzalo, C; Ramon, C; Glenny, J; Koretzky, M; Porto, A; Tiberio, O; Ellenberg, A; Saurral, R; Igarzabal, C; Vilamajo, O Gomez; Matkovich, J; de Lapertosa, S Gorban; Villagra, Mirtha; Cuzziol, G; de la Cruz, M; Pinchetti, R; Mierez, M; Lopez, C; Gorosito, V; Gabito, A; Kleiban, A; Grosembacher, L; Adrian, P; Paula, R M; Javier, G; Kraft, F; Andres, F; Krynski, F; Nicolas, P R; Marcelo, F; Alfredo, F A; de la Fuente, R Leon; Natalia, C; Luquez, H; Recuero, Yanina; Becchetti, N S; Ruiz, M; Costantino, M; Vazquez, G; Guzman, C; Pelatia, P; Maffei, L; Sassone, S; Yantorno, M; Prado, G; Khron, B; Maldonado, N; Gustavo, L; Veronica, V P; Marino, J; Viviana, C; Elizabeth, A; Alejandra, C; Oscar, R; Azize, G Moises; Gallardo, Mariela Yanez; Escudero, M L; Vargas, E; Ramos, H; Lucero, C; Najenson, M; Crocci, I T; Chiesa, A; Nardone, L; Dominguez, S; Manghi, F Perez; Grossman, M; Giudice, G L; Romeo, A; Piskorz, D; Miguel, C; Susana, D; Noeli, U; Rosa, S; Martin, V Quevedo; Soledad, A M; Virginia, M M; Lorena, G M; Prado, A; Veronica, L; Eduardo, H; Adolfo, P G; Florencia, W; Rista, L; Scolari, C; Rojas, N; Bertolio, V; Zarandon, R Saa; Jair, S; Orlando, C; Sanabria, H; Ignacio, De U; Marina, R C; Sarjanovich, R; Scaro, G; Huerta, C M; Schiavi, L; Mana, M; Gutierrez, M; Dain, A; Gavicola, R; Sessa, H; Sacripanti, J; Felman, R; Vilarino, P; Sicer, M; Lagrutta, M; Sala, J; Casabella, T Smith; Cecilia, H M; Carlos, B; Vines, G; Javier, R; Vico, M; Lanchiotti, P; Martella, C; Torres, L; Villarino, A; Molina, M P de Valle; Martinez, J M; Farias, C; Bertola, S; Rojas, M; Guzman, P N; Nisi, J S; Martinez, D F; Barrionuevo, M; Vita, N; Lopez, A; Vottero, E; Giuliano, M E; Paron, L; Vogel, D; Mele, P; Imposti, H; Dominguez, A; Zaidman, C; Fernando, G; Beck, M de Oliveira; Beltrame, P A; Chemello, D; Junior, R Magalhaes Montenegro; Abreu, A P; Fernandes, V; Saboia, J; Rodrigues, L; Carvalho, M; Gurgel, M H; Gadelha, D; Ramos, C Slompo; Borba, V Z C; Golbert, M Moyses; Pitthan, M; Golbert, L; Valentini, R; Gross, J L; Canani, L H; Valenti, A M; Sartori, C C; Dutra, O Pereira; Azevedo, E; Azevedo, A; Vaz, R; Vaz, H; da Costa, Fe Alves; da Costa, L M Alves; Panarotto, D; Lain, F V; Camazzola, F E; Dellomea, B S; Rech, R; Pizzato, P E; Nunes, C E; Jaeger, C; Silveira, D; Wagner, L; Machado, L F G; Rea, R Roginski; de Bem, A Boeving; Alves, J M; Jonasson, T H; Malucelli, F J; Betti, R Barcellos; Lerario, A C; Lisboa, H Kurtz; Batista, J; Bem, J; Tres, G; Tavares, C B; Nardi, A; Pozzatto, M; Backes, L; Reolao, J B C; Scariot, E; Ziguer, E; Baldissera, D M B; Griz, L Maciel; Antunes, D; Victor, F; Freire, K; Barros, A; Costi, B; Sa, M; Carneiro, A; Felicio, J Soares; Felicio, K; Penha, P; Ferreira, J; Melo, F; Alves, A; Souza, A C; Costa, L; Pinheiro, D; Andreotti Turatti, L; Augusto, G A; Leanca, C C; Santomauro Junior, A C; Costa e Forti, A; Sena, R; Marinho, A E; Facanha, C; Barroso de Souza, K; Barroso de Souza, A S; Barroso de Queiroz, W C; de Oliveira Leite, S; do Carmo Vieira, S; Ramos Gubert, L F; Olsen, A C; Piazzetta, G; Fuck, A R; Ferreira, M A; Ribas Fortes, J; Drulla Brandao, T J; Padilha, M; Alves, F; Radice, E; dos Santos, J A; Simoes de Almeida, R; Franco, D M; Saporito, W F; Goldberg Eliaschewitz, F; Reis Franco, D; Nunes de Siqueira, K; de Carvalho Camara Bona, R; Rizzo Genestreti, P R; Costa de Castro, D L; de Lima Visconti, G; Pinho da Silva Sampaio, C R E; de Almeida Palhares, F; Konigsfeld, H P; Alves, E F; Kauffman Rudenberg Feder, C; de Almeida Leao, B D; Saraiva, J Kerr; Rodovalho, S; Martins Costa, M K; Fraccari Pires, N; Lanna Figueiredo, E; Werner, G F; de Faria Garcia, J C; Viana de Paiva, I; Gomes Quirino, B E; Vieira Botelho, R; Alves da Silva, R; Cautella Navarro, A L; Lourenco, C; Donizetti de Sena Pereira, A; Britto Arantes, F B; Boner, D S; Abdalla Saad, J; Belisario Falchetto, E; Kei Marquesini Washizu, E; Mandil, A; Pimenta, N L; Tofani, F A; Fonseca, T F; Teixeira, L A; Maia, L; Benes Teixeira Lemos, M A; Coelho Costa Mouco, O M; Arruda Nakazone, M; Reis Katz Weiand, L; Bohn, J M; Nasser Hissa, M; Hissa, M; Araripe, F; Carvalho, F; Cancado, G B; Wang, R; Chacra, A; Fusaro, A S; de Mendonca, E; Cercato, C; Halpern, A; Alves, B B; Braga Braile, M; Sestito, R S; Mustafa, E M; Ribeiro Ferreira, V R; Sbardellini, B C; Sales de Almeida, P D; Villaca Guimaraes Filho, F; Piedade, M M; Ribeiro de Castro Bienert, I; Braga, J F; Saes Braga, J M; Sartori Daher, R A; Rodrigues, A; Barreto da Silva, R A; Franco Hirakawa, T; Elias Terra, E; Cavalcanti Farias, E; Gabriela de Faria Figueiredo, M; Casari da Silva Lima, L; Barbosa Kersten Moraes, K; Avelino, I; Prync Flato, U; Plavnik, F L; de Souza Portes, E; Moreira, M E; Vendramini, M; Veloso, R; Adam, R; Santos, S; Sayeg, N; Almeida Guerrero, D; Madeira, M; Siqueira, J; Pinheiro, R; Villacorta, A; Mellazi, A C; Braga, T; Kaiser, S; Paolino, B; Lefterov, I; Marinchev, A; Angelova, S; Klyuchkova, N; Lybomirova, Z; Kerekovski, Y; Kuneva, T; Penkova, D; Levterov, G; Videnova, E; Georgieva, P; Shinkov, A; Borissova, A M; Vlahov, J; Dakovska-Dekova, L; Temelkova, M; Borisova, K; Tsenov, S; Andreeva, V; Margaritov, V; Arasheva, G; Lozanov, L; Borisov, R; Gorcheva, D; Henein, S; Whatley, S; Boutros, M; Kalyniuk, N; Berlingieri, J; Nisker, W; Hoag, G; Hepburn, D; Harvey, M; Manjoo, P; Yale, J; Sherman, M; Tsoukas, M; Rehman, W; Mason, M; Santerre, M; Barkhuizen, F; Rooke, C; Gill, C; Kooy, J; Burgoyne, G; de Kock, J; Degen, G; Hockman, L; Invik, R; Roberts, P; Ward, K; Alasaad, H; Susan, Abdel-Salam; Davies, V; Gupta, N; Milhalidis, J; Grossman, L; Agawal, N; Yared, Z; Rwaheed; Nouhad, S; Nahla, A -J; Khandwala, H; Warwick, A; Wadehra, D; Manan, A; Vecchiarelli, J; Aslam, N; Ferrao, A; St-Maurice, F; Collette, R; Davey, Bruce; Nawaz, Sarah; Coutu, B; Costi, Paolo; Greiss, I; Mansour, F; Raymond, J -M; St-Phard, W; Nadra, I; Della Siega, A; Barahona, L Vasquez; Klinke, P; Contractor, H; Fryer, M; Chandra, N; Conti, B; Telzer, L; Robinson, S; Sorensen, S; Cara, H; Lounsbury, N; Martin, E; Mitchell, L; Pelzer, E; Nelson, S; Jones, M; Cox, J; Luco, G; Trhoughton, T; Nawaz, S; Labonte, R; Chouinard, G; Frechette, A; Rheaume, M -C; Cusson, J; Faucher, J -P; Dery, V; Kelly, A; Miranda, B Wai-Ling; Al-Kayssi, N; Malette, P; Rheault, P; Fredette, P; Dumas, R; Palardy, J; Belanger, A; Boucher, P; Doyon, B; Charbonneau, J; Bailey, G; Odendaal, M; Stephan, K; Badenhorst, J; Knight, D; Thurgood, A; Johnston, M; Cooper-Rosen, E; Jagger, R; Green, M; Weisnagel, S John; Gangloff, A; Bergeron, J; Pesant, Y; Chevalier, P; Woo, V; Hurd, C; Eggers Ruckert, G; Lira, J I; Navarro, G; Rodriguez Venegas, M; Gonzalez, P; Garcia, M; Montecinos, H; Araneda Vidal, G A; Fernandez, M J; Varas, J P; Fernandez, C; Aguilar, J; Marin, R; Conejeros Kindel, C R; Yovaniniz, P; Kuzmanic Gherman, O; Aravena, M; Palma Carvajal, J C; Macias, E; Corrado, P; Opazo Lazcano, M; Garrido, B; Charme, G; Celis Carrasco, J Cristobal; Vignolo, P; Saavedra, S; Saavedra Gajardo, V A; Saavedra, C; Santamaria, D; del Castillo, B; Balda, I; Zurvarra, V; Fu, G; Jiang, D; Huang, H; Wang, M; Song, J; Lu, W; Lin, Y; Lu, Z; Shi, Y; Zhong, M; Zhao, X; Chen, Di; Zhang, G; He, Y; Shi, P; Chu, K; Gao, Q; Deng, W; Chen, H; Zhang, J; Zhang, Y; Li, Z; Liu, E; Xie, Y; Lin, R; Tan, W; Yuan, Z; Wang, Y; Ren, J; Yu, H; Luo, M; Ma, W; Shi, W; Xu, H; Xu, M; Liu, G; Dong, Y; Dong, X; Bai, B; Guo, R; Liu, X; Gao, Y; Li, S; Xu, X; Liu, P; Chen, D; Wang, S; Fu, F; Jiang, Q; Meng, C; Yin, X; Lu, Y; Cui, Y; Su, G; Miao, W; Wei, F; Zhao, Q; Gao, X; Lozno, H Yupanqui; Prada, W Andres; Ordonez, A Maria Garcia; Quintero, E; Vallejo, G Sanchez; Contreras, C; Escobar, J; Alvaran, J P Jepez; Ortiz, L Garcia; Marin, M; Montoya, C; Mendoza, J Accini; Manjarres, J Santander Rosales; Navarro, B; Martinez, G Aroca; Bonfanti, A A Cadena; Perci, X Lastra; de la Hoz, L; Arroyo, J Coronel; Rendon, C P Lenis; Lopez, J M; Escobar, N; Rendon, C Lenis; Franco, J A Ochoa; Lozano, M Terront; Zapata, C Bazurto; Ibarra, L S Garcia; Barrero, A M Rodriguez; Sarmiento, A F; Lozada, H Garcia; Olitte, M M Diego; Florez, L E Rengifo; Munoz, C Jaramillo; Quintero, G E Nanclares; Correa, G M; Ruiz, S; Dorado, A Gonzalez; Causa, A; Lozano, J; Palma, E Arcos; Morales, A; Arteaga, J; Beltran, J; Granados, M; Rubio, A C; Dada, F Trujillo; Bueno, Wendy; Rivera, R Cano; Corredor, K Johenis; Romero, V Maria; Accini, F Alberto Trujillo; Palmera, J Mario; Ortega, M Rivas; Garcia, C Elena; Sanchez, A M Morales; Lora, Y Beatriz; Escobar, J Montoya; Cano, J Ignacio Garcia; Duque, S Milena; Thiriez, S Mora; Castano, M Luz Munoz; Giraldo, P Andrea; Boljkovac, Z; Grcic, I Sunic; Balen, M Jandric; Zukanovic, S; Jeric, M; Dvorscak, D; Car, S; Knezevic, A; Herceg, D; Franov, B; Miskovic, V; Bakula, M; Hadak, A; Superba, M; Rubes, J; Gornik, I; Hamzic, J; Ballek, L; Sedlackova, L; Hejlova, J; Galatikova, D; Huskova, A; Zak, P; Flekac, M; Mraz, M; Potuznik, P; Novak, P; Okenka, L; Matuska, J; Rohac, F; Vondrak, K; Reichert, P; Shamasna, A; Skopek, J; Lejskova, M; Jiruska, M; Lang, P; Podoubsky, R; Svobodova, J; Cifkova, R; Jozifova, M; Krajcoviechova, A; Wolfhart, P; Sulc, P; Silhova, E; Cechakova, M; Machova, V; Balkova, J; Peterka, M; Votocek, S; Prosecky, R; Valis, M; Barton, P; Tomek, J; Pumprla, J; Axmannova, Marketa; Vitaskova, R; Sincl, F; Horanska, P; Richter, B; Malicherova, E; Roderova, E; Jenickova, P; Winkelmann, B; Finger, C; Klausmann, G; Milek, K; Schwabe, M; Weiss, N; Mahlmann, A; Werth, S; Schmidt, C; Schiefke, I; Schwittay, A; Kornmann, O; Eich, A; Franke, S; Kis, J; Szobota, E; Danos, P; Beke, E; Grosz, A; Csecsei, G; Ferenczy, J; Filo, A; Ferencz, I; Mihaly, E; Baranyi, T; Revesz, K; Schlezak, J; Harcsa, E; Dombroczki, Z; Kocsis, I; Juhasz, E; Literati-Nagy, B; Kulcsar, E; Bezzeg, K; Kemeny, V; Peterfai, E; Buday, B; Keltai, K; Balo, T; Somogyi, A; Nagy, G; Oroszlan, T; Bagosi, Z; Bujtor, Z; Tabak, A; Ferencz, V; Domjan, B; Tanczer, T; Palinkas, A; Karolyi, H; Kovacs, K; Csaszar, I S; Palhegyi, E; Engelhalter, G; Horthy, R; Vanko, E; Szabo, G; Sipos, G; Szigyarto, M; Sebo, N; Paragh, G; Zsiros, Noemi; Szentimrei, R; Pal, D; Kobling, T; Szanto, I; Varadi, Z; Bajnok, L; Szujo, S; Nemes, O; Bajnok, A; Mezosi, E; Bodis, B; Marton, Z; Konyves, L; Farago, M; Kiss, G; Kiss, Orsolya G; Nagy, E; Takacs, R; Nyitray, S; Abraham, G; Fehertemplomi, K; Chiu, Kuan-Ming; Deak, L; Dezso, E; Deeb, D; Karneili, E; Zloczower, M; Mahmid, R; Zolotov, S; Hochberg, I; Elias, M; Goldstein, L H; Poletaev, V; Rock, W; Koren, O; Saliba, W; Wolf, F; Adawi, F; Nimer, A; Mosenzon, O I; Raz, I; Potekhin, M; Cahn, A; Wainstein, J; Feldman, D; Yulian, T; Zvulunov, E; Israel, H; Shpitz, D; Bar-Or, I; Chananashvili, L; Irena, L; Dessau, H; Halabe, A; Vishlitzky, V; Nabriski, D; Baraf, L; Itelman, M; Schiff, E; Willner, N; Fireman-Klein, E; Svistunov, V; Dotan, Y; Pavlichev, O; Saig, L; Bashkin, A; Kuyantseva, E; Gershkov, S; Nodelman, M; Arbel, Y; Bogomolny, N; Leshem-Rubinow, E; Rofe, M-T; Chorin, E; Havkuk, O; Fujino, Y; Kitamura, H; Toriumi, Y; Ishiguro, H; Naganuma, T; Shu, S; Suzuki, K; Hirota, Y; Hayashi, T; Hozawa, K; Fukui, T; Abe, Y; Yamauchi, K; Maruyama, M; Matsumura, S; Kozuma, R; Nagai, Y; Kihara, Y; Maeda, H; Nakanishi, K; Iitsuka, T; Hatori, M; Shinozaki, Y; Akiyama, D; Kawabe, M; Takei, M; Sato, A; Kawai, Y; Kitajima, K; Ide, M; Sato, N; Morisaki, H; Nakashima, K; Takayanagi, H; Watanabe, H; Iwahashi, N; Tsujimoto, M; Hibuse, K; Hata, T; Ueno, K; Tatsuma, H; Wakida, Y; Ito, Takahumi; Mizuno, R; Fujita, H; Konishi, N; Kanehira, T; Watanabe, R; Miyaoka, H; Okada, T; Yamamoto, M; Okita, S; Murakami, H; Todo, Y; Umeoka, F; Hori, K; Shiraishi, K; Tada, F; Shimizu, T; Tamai, J; Sasaki, C; Okuzima, Y; Yasuda, M; Iwaita, Y; Tanaka, K; Rha, Seung-Woon; Na, Jin Oh; Cho, Deok-Kyu; Cho, Yun-Hyeong; Hwang, Eui Seock; Choi, Tae Young; Won, Ki-Bum; Kim, Hong-Bae; Kim, Sang-Hwan; Oh, Dong-Jin; Lee, Jae Hyuk; Choi, Hye Min; Chung, Hye Soo; Park, Hyung-Bok; Suh, Yong-sung; Kim, Sin Gon; Kim, Hee Young; Kim, Yoon Jung; Kim, Nam Hoon; Kim, SunHwa; Kim, Kyeong Jin; Kim, Kyoung Jin; An, Jee Hyun; Kim, Joo Hyung; Park, Kyong Soo; Kwak, Soo Heon; Kim, Min Kyeong; Park, Kyeong Seon; Hwangbo, Yul; Lee, Dong-Hwa; Hong, A Ram; Kim, Lee-Kyung; Kim, Kyongyoung; Oh, Chang-Myung; Lee, Jie Eun; Moon, Shinje; Jung, Chan-hyeon; Lee, Ji Hyun; Jin, Ji Myeong; Hyun, Bae Jae; Yang, Ye Seul; Kong, Sung Hye; Yoon, Kun Ho; Yang, Hae Kyung; Kim, Hun-Sung; Hong, Taek Jong; Oh, Jun-Hyok; Park, Jin Sup; Lee, Hye Won; Choi, Jung-Hyun; Ahn, Jinhee; Han, Sang-Jin; Park, Woo Jung; Kim, Hyun Sook; Park, Kyung Ha; Jo, Sang Ho; Kim, Sung Ai; Kim, Moo Hyun; Park, Jong Sung; Suh, SungHwan; An, Won Suk; Park, Mi Kyoung; Cho, Young Rak; Kim, Young-Hak; Lee, JongYoung; Lee, Seung-Whan; Kim, Dong-Soo; Jin, Han-Young; Seo, Jeong-Sook; Chung, Choon Hee; Lim, Jung Soo; Huh, Ji Hye; Park, Ie Byung; Yu, Seung Hee; Sim, N Zulkarnain; Khan, S Shah Firdaus; Albakari, N I M; Sivaraman, J M; Manaf, K A A; Maharuddin, I Wan; Nagendram, S V; Ali, N; Abdul Latiff, N A; Othman, N Ezzean Ezzati Mohd; Sarip, Siti Norsaadah Md; Chew, E; Mohamed, S; Aziz, N Azizah; Hui, K Chong; Lin, L Shueh; Velaiutham, S; Khir, A Sharifuddin Mohd; Lee, L Yuan; Manikam, S Devi; Chooi, K Chiew; Chang, M Lee; Ooi, C Peng; Anthony, J Anthony; Seganathirajah, Mitra C; Ng, Ooi Chuan; Ismail, Norzian; Cheah, C W Kooi; Ramanathan, G R L; Mui, Ng Yoke; Wen, Fu Kok; Choo, Teh Lei; Bin Ruhani, A Irawan; Jamaludin, S; Abidin, S Khairani Zainal; Nor, F Safhan Mohamad'; Abu Hassan, M Radzi; Hanari, N; Ahmad, N Shahrazal Binti; Suan, M Azri Bin Mohd; Zainul, N Hanim; Ali, S Maisarah Binti Md; Han, C Kok; Sridhar, G Srinivasaiah; Chin, A Choon; Vin, L Zhen; Kadir, K Abdul; Zain, A Zaini Md; Hussain, N Asmah Nik; Pusparajah, P; Flores Lozano, F; Cabeza Gomez, A; Calarco Zaccari, E; Barragan Vigil, A Maria; Anaya Preciado, C Margarita; Guerrero de Leon, M C; Fernandez Parra, M Candelaria; Lopez Cervantes, A; Trevino Aguirre, E; Pelayo Orozco, E; Caballero Gonzalez, S; Banda Elizondo, R Guadalupe; Rosa Flores, E Santa; de Leon Guerrero, M Angel Garcia; Jimenez Flores, F; Perez Sanchez, J; Liana Perez, F; Castillo Rodriguez, J Salvador; Alberto Martinez, L; Roman Marquez, D; Figueroa Gutierrez, B Estela; Escalona Flores, M Teresita; Aguilera Real, M; Fajardo Campos, P; Fajardo Garcia, P; Uribe Rios, M Arasely; Palomo Romero, E; Reynoso Perez, Z; Lopez Tarabay, C; Abraira Munoz, L David; Garcia Ibarra, L; Gutierrez Farias, J Jaime; Garcia Gonzalez, J; Alvarez Palestino, N; Arce Sanchez, L; Avila Carrillo, G M; Martinez Flores, M Angel; Nava Ordonez, N; Medina Pech, C; Arana Andrade, M Jesus; Uicab Euan, J David; Elizabeth Ortegon, M; Zuniga Garcia, S Alicia; Tamayo y Orozco, J; Cacique Vazquez, H de Jesus Alfredo; Villanueva Herrera, R; Vera Perez, E Karla; Ponce Arango, A; de los Rios Ibarra, M Odin; Gonzales, L; Rubio Esperano, J de Jesus; Serrano Quintana, L Lizet; Salazar, I; Nevarez Ruiz, L; Carmona Barron, C Agustin; Garcia Ballesteros, C Bernardette; Flota Cervera, L Fernando; Canto Hercilla, E Antonio; Gomez, H; Villagordoa Mesa, J; Aguado Herrera, P; Pena Rodriguez, M Del Pilar; Orozco, E; Gutierrez Ochoa, R; Verduzco Mora, E; Riojas Charles, C; Araujo Silva, R; Sanchez Mijangos, J; Angel Guerrero, M; Cuevas Diaz, C Leticia; Ortiz Zavala, C; Frenk Baron, P; Rangel Bernal, A; Luna Martinez, F; Gutierrez Tlapale, M; Franco Ramirez, E; Martinez Basila, A; Ceja Munguia, R Maria; Uribe Tello, M; Guagnelli Martinez, M Angel; Mulder, H; van der Graaff, P; Keller, I Klopping; Schoofs, M; Smak-Gregoor, P; Al-Windy, N; Bulut, S; de Jong, J; Maas, A; Schaardenburgh, P; Imholz, B; Heijster, J; Hoogenberg, K; Smit, C J; Kooy, A; Huvers, F; Landewe-Cleuren, S; Kars, M; van Moorsel, D; Wolffenbuttel, B; Lutgens, H; Schutte, E; Gansevoort, R; Idzerda, N; Westerink, J; Weijmans, M; vd Berg, J; van Kleef, M; Slob, M; Jaspers, N; Hovens, M; Monajemi, H; Kobielusz-Gembala, I; Zmuda, W; Adamczyk, M; Konieczny, M; Strzelecka-Sosik, A; Nowacka, E; Wozniak, I; Krzyzagorska, E; Sekulska, Marzenna; Kaczmarek, B; CzajkowskaKaczmarek, E; Opawska, K; Dabrowska, M; Kus, W; Wrzesien-Kus, A; Piotrowski, G; Hotlos, L; Ocicka-Kozakiewicz, A; Jurowiecki, J; Stasinska, T; Karczewicz-Janowska, J; Jaruga, J; ZytkiewiczJaruga, D; Krupinska, E; Pupek-Musialik, D; Bogdanski, P; Szulinska, M; Skrypnik, D; Skokowska, E; Bojarska-Los, M; Giermkowska-Samek, M; Pirog, M; Wojnowski, L; Jelinska, A; Gradzka, M; Danyluk, A; Lysek, R; Sliwinska, T; Podrazka-Szczepaniak, A; Barney, M; Tomczyk, A; Necki, M; Malicka, J; Dudzinska, M; KiszczakBochynska, E; Markiewicz, A; Galbas, K; Paciorkowski, A; Mazur, S; Mazur, M; Chmielowski, A; Swiatek, A; Sobocka, B; Wis, J; Jozefowska, M; Kaczmarek, M; Timler, M; Lazuka, L; Lazuka, N; Jasiel-Wojculewicz, H; Stefanski, A; Wierucki, L; Hanczuk, A; Misiura, M; Szmygel, K; Kolcowa, O; Orlowska-Kunikowska, E; Rutkowski, M; Ignaszewska-Wyrzykowska, A; Popenda, G; Maciejewska, J; Mostowy, A; WojteckaGrabka, M; Grazyna, M L; Wieslaw, K; Barbara, K; Kramarczuk, E; Wojciech, C; Jaroslaw, H; Ewa, B; Karas, P; Agnieszka, Strzelecka-Sosik; Hanna, C; Justyna, S; Piotr, K; Mateusz, W; Katarzyna, W; Jacek, F; Andrzej, J; Cymerman, K; Gmytrasiewicz, M; Zambrzycki, J; Opadczuk, P; Krysiak-Kowaluk, H; Klodawska, K; Klszczewski, Z; Zieleniewski, J; Urbanska, K; Faran-Grabowska, K; Szczepanik, T; Siegel, A; Kleczek, A Strzala; Kincel, K; Nowak, D; Slowik-Gomulka, L; Watemborska-Matuszyk, G; Lampart, J; Strozik-Krecichwost, A; Dziewit, T; Broncel, M; Wojcik-Odyniec, J; Jakubczyk, E; Wierzbicka, K; Witowicz, A; Jedrych, B; Korczyk, P; Socik-Pojawa, M; Monteiro, P; Monteiro, S; Lazaro Mendes, P; Soares, F; Lazaro Mendes, S; Leite, L; Vicente, J; Santos, M; Ferreira, A R; Alves, P; Rosario, F; Garrao, A; Duarte, L; Rogado, C; Duarte, R; Laginha, T; Matos, P; Raposo, J; Mariz, J; Teixeira, J; Capela, C; Leitao, A; Cardiga, R; Alface, M; Augusto, S; Basto, L; Ribeiro Cunha, A; Rei, D; Dantas, J; Verdasca, I; Andrade, L; Mafalda Silva, A; Elena Suarez, M; Paixao Dias, V; Silva, J; Moreira, M; Pereira, N; Goncalves, M; Goncalves, A; Silveira, A; Sampaio, A; Dias, A; Diogo, M; Vilaca, C; Cif, A; Calin, T; Elena, S Mirela; Crisan, C; Adina, S; Ramona, S N; Anghel, V; Simona, C; Turcu, L; Mihaela, V; Cosma, D; Cristina, H Delia; Marius-Calin, H; Negrisanu, G; Andreea-Andrada, M; Maria-Mihaela, V; Camelia, T Simona; Oana, P; Monia, A; Onaca, A; Mircea, O; Mot, A; Stolea, V; Elena, N; Barbonta, D; Cristian, B; Oana, S; Ioana, A; Popescu, A; Madalina, M; Coman, A; Anca, C; Constantinescu, S; Mircea, C; Diaconu-Sotropa, M; Ene, D; Pintilei, E; Mihai, G; Delia, R Pintilei; Toarba, I; Simona, H; Negru, D; Flaminzeanu, Ferdinica-Loredana; Iulian, C; Maria-Cristina, C Ana; Doros, R; Cleo, S Gabriela; Sorin, B; Demian, L; Mihai, S; Raul, B; Nicolau, A; Cosmin, P Mihai; Isabela, G; Elena, C; Ileana, T; Valuyskikh, E; Miroshnichenko, E; Klementyeva, N; Zelman, O; Chumakova, G; Vigel, A; Leonova, N; Pergaeva, Y; Stefanovskaya, O; Pushkareva, S; Antoshkina, L; Zheleznova, N; Iveitsman; Barbarash, O; Zvereva, T; Zhuravleva, E; Zavyrylina, I; Usoltceva, E; Savostyanova, Y; Kupriyanova, T; Krivoshapova, K; Kondyukova, N; Inozemceva, A; Argunova, Y; Tsyba, L; Belenky, D; Mariich, O; Terekhova, A; Tsygankova, O; Kuznetsova, E; Nagibovich, G; Ivchenko, Y; Dobronravov, V; Dobronravov, A; Bush, M; Trofimenko, I; Vishnevsky, A; Zikov, V; Kositsyn, D; Palzman, Z; Spiridonova, T; Rodina, N; Polozhentsev, S; Mamedova, L; Panov, A; Abesadze, I; Alugishvili, M; Ivashkin, V; Drapkina, O; Korneeva, O; Zyatenkova, E; Glinkina, I; Poluboyarinova, I; Gurova, O; Raykhman, A; Vertkin, A; Rodykova, I; Shamaeva, K; Petrovskaya, T; Uzueva, E; Milovanov, Y; Milovanova, S; Milovanova, L; Markina, M; Dobrosmyslov, I; Markov, V; Afanasiev, S; Babich, E; Belokopytova, N; Demyanov, S; Maximov, A; Maximov, I; Rebrova, T; Shtatolkina, M; Masin, A; Demko, A; Chuyko, O; Pronina, A; Charf, G; Akatova, E; Urlaeva, I; Nikolin, O; Khovaeva, Y; Ermachkova, L; Burdina, E; Shvalb, P; Suchkov, I; Pshennikov, A; Gryaznov, S; Rymar, O; Dolinskaya, Y; Bahareva, Y; Mustafina, S; Sherbakova, L; Ovsyannikova, A; Bolshakova, O; Polunicheva, E; Dora, S; Agafyina, A; Yashina, A; Vasilieva, I; Yakhontova, P; Selivanova, S; Kargapoltseva, O; Shilina, N; Bayramova, G; Sorokin, I; Astamirova, K; Kuchuk, P; Koniushenko, D; Malykh, N; Dvorkin, M; Krovelets, T; Konovalova, K; Seeber, M; van Niekerk, F; Siebert, H; Steenkamp, W; Wiid, S; Noeth, M; Siebert, R; Breedt, J; Bouwer, J; Kapp, C; Venter, T P; Rayner, B; Trinder, Y; Rheeder, P; Delport, E; Mathijs, S; Soma, P; van Zyl, D; Strydom, M; Marais, A; Badat, A; Hansa, S; Fourie, D; Walton, T E; Engelbrecht, J; Jansen, J; Roos, J; du Toit, S; Lehloenya, K; van Zyl, L; van Zyl, F H; Naude, M; Mookadam, M; van der Merwe, A; Trokis, J; Lombard, L; Coetzee, K; Ismail, S; Bruning, H H; Latiff, G; Yasmin, O; Pillay, T; Mohamed, Z; Dawood, S; Stapelberg, A; Abrahams, P; Jurgens, J; van Heerden, P; Swart, E; Botha, C Jacobus; Meeding, J; Hemus, A Colleen; Oosthuysen, W; Visagie, G Jacobus; Fourie, N; Hutton, P Alexander; van der Merwe, N Daniel; Chelin, N; Everton, T C; Duki, M; Ghila, N M; Joshi, M; Hira, M; Tinahones Madueno, F; Martinez, B; Sebastian, N; Asmarats Mercadal, L; Calzado Isbert, S; Diaz Gonzalez, I; Masso Asencio, J; Coves Figueras, M Jose; Cuatrecasas Cambra, G; Rivas, M; Garcia, H; Roca Fusalba, A; Geat, D; Abadal Sastre, J; Cereto Castro, F; Carrasco Mas, A; Morales Portillo, C; Serrano, I; Valdes Hernandez, S; Linares Fajardo, F; Sanchez Juan, C; Carlos Ferrer, J; Gomez Peralta, F; Abreu Padin, C; Mauricio, D; Soldevilla Madorell, B; Vazquez San Miguel, F; Pedrol, N Alonso; Trescoli, C; Fajardo Montanana, C; Angeles Gonzalo, M; Lara Capellan, J Ignacio; Estrella, A; Vazquez Martinez, C; Gonzalo Montesinos, I; Rovira Loscos, A; Blanco Coronado, J; Pantoja Perez, J; Vizcaino Castillo, B; Castro Alonso, C; Escudero Quesada, V; Gorriz Teruel, J Luis; Narejos Perez, S; Geraldia Lama, M; Garcia del Rio, E; Zlova, T; Ponomarenko, K; Karpenko, O; Bezuglova, S; Mitskevych, L; Kizim, S; Nevolina, I; Katerenchuk, V; Liudmyla, B; Ivan, K; Rudyk, I; Olena, M; Anna, I; Ganna, B; Topchii, I; Semenovykh, P; Yulia, Y; Mykhalchyshyn, G; Kirienko, D; Kobiliak, N; Dr Bodnar; Dr Mykhalchyshyn; Pertseva, N; Olena, G; Tomashkevych, H; Mostovoy, Y; Korpachev, V; Prybyla, O; Tronko, M; Kovalchuk, A; Kushnarova, N; Zinych, O; Tseluyko, V; Andriy, Z; Olga, R; Mankovskyy, B; Zherdova, N; Lykhoshapko, O; Logoida, P; Godlevska, O; Olena, V; Olga, C; Gyrina, O; Alifer, O; Dozhuk, K; Pekhenko, V; Gorobets, N; Korneichuk, A; Makarenko, E; Martynyuk, L; Martynuyk, O; Stanislavchuk, M; Larysa, P; Natalia, S; Botsyurko, V; Kostitska, I; Dzeman, O; Ablitsov, Y; Ivaseiko, S; Konovart, O; Sandurska, S; Vendzilovych, Y; Samoylov, O; Iryna, C; Rozhkivska, L; Ulyanchenko, I; Kateryna, V; Orlenko, V; Ivaskina, K; Tronko, K; Pashkovska, N; Stankova, N; Vynnychenko, L; Bolotnikova, N; Demokhova, N; Reshotko, D; Popova, A; Dr Bogdana; Tetiana, S; Svitlana, D; Oksana, R; Vlasenko, M; Litvinova, S; Semenyuk, I; Fishchuk, O; Tkachenko, T; Ovcharuk, M; Rasputina, L; Vakaliuk, I; Tymochko, N; Drapchak, I; Petrovska, L; Lai, Wen-Ter; Yen, Hsueh-Wei; Lu, Ye-Hsu; Voon, Wen-Chol; Lin, Tsung-Hsien; Cheng, Kai-Hung; Chiu, Cheng-An; Chu, Chun-Yuan; Chu, Chih-Sheng; Hsu, Po-Chao; Chiang, Chern-En; Li, Yi-Chun; Kuo, Chin-Sung; Lin, Shing-Jong; Lin, Liang-Yu; Chao, Tze-Fan; Yu, Wen-Chung; Sung, Shih-Hsien; Wang, Kang-Ling; Lu, Tse-Min; Shih, Kuang-Chung; Wu, Cho-Kai; Chiang, Fu-Tien; Hwang, Juey-Jen; Tsai, Chia-Ti; Juang, Jyh-Ming; Jeng, Jiann-Shing; Tang, Sung-Chun; Lai, Chi-Cheng; Huang, Hung-Ru; Cheng, Chin-Chang; Hsieh, I-Chang; Hsieh, Ming-Jer; Chen, Chun-Chi; Lee, Cheng-Hung; Pai, Pei-Ying; Ko, Po-Yen; Wang, Tzu-Yuan; Chen, Tien-En; Wu, Hung-Pin; Chang, Shih-Sheng; Chen, Ke-Wei; Lin, Yen-Nien; Hsieh, Li-Chuan; Chou, Che-Yi; Jiang, Ju-Ying; Chen, Hua-Fen; Lee, Ming-Tsang; Huang, Jih-Hsin; Chen, Jer-Shen; Tsai, Liang-Miin; Chen, Ju-Yi; Lee, Cheng-Han; Chen, Po-Sheng; Saxena, M; Collier, D; Vaidya, B; Harman, S; Ramell, M; Davies, M; Chatterjee, S; Meakin, L; Quinn, M; Bain, S; Mallipedhi, A; Min, T; Bashir, J; Blagden, M; Ali, J; McCrimmon, R; Brennan, G; Malcolm, E; McDonald, D; Pearson, E; Illsley, G; Darzy, K; Winocour, P; Hanif, W; Cockwell, P; Charlton, M; Thekkepat, S; Howat, I; Devers, M; Patrick, J; Wyatt, N; Smith, C; Singh, B; Nicholas, J; Gillani, S; Green, F; Bell, E; Boyle, J; MacKin, S; Livingstone, R; Arif, A; Syed, M; Hammoud, J; Sparks, J; Anderson, M; Tumey, R; Condit, J; Reddy, M; Abalos-Galito, M; Rebecca, J; Barker, T; Seaton, B L; Campbell, E S; Kompanik, H C; Jayson, L V; Huffman, C; Bialow, M; McDonnell, G F; McCaffrey, J Kerr; Manis, C Anne; DeLuca, E A; Levins, J; Bartlett, M; Anorga, K; Franco, M; Gentry, P; Hodge, D; Pohil, R; Rschultz; Leggett, R; Blair, L; Gisler, J; Niegos, F; Osburn, M; Parma, K; Schendel, S; Stines, L; Winnie, M; Wu, P; Canales, J; Yu, J; Cornett, G; Beavins, J; Hyde, D; Zapinski, D; Johnson, T; Levinson, D; Ahmed, A; Kenny, B; Kuehl, A; Bates, C; Jantzi, C M; Ananthula, P D; Shafer, J G; Louthan, J D; Bays, A Renee; Stapleton, A N; Staton, P T; Strum, D L; Taylor, P; Smith, A N; Rapp, R; Bao, S; Randolph, C; MacGillivray, B; Schuster, R; Harden, T; Barnella, C; Dunnam, T; Whiles, R; Bolick, C; Brockmyre, A; Plucker, S; Marshall, C; Poteet, C; Morin, D; Tavel, E; Averill, N; McFann, A; Purcell, D; Dixon, T; Corey, Ericksen; Goss, J; Drescher, R; Irfan, M; Naeem, M; Egelhof, R; Mehta, P; Koehler, T; Walia, J; Fernandez, J Alea; Bedel, G; Preet, R; Bhuchar, S; Arroyo, J M; Ahmed, F; Onyema, D; Benchabbat, Albert; Kohanbash, Leon; Miller, P; Lalinde, M; Carrithers, E; Patterson, R; Raube-Miceli, A; Martinez, A; Harris, B; Levy, R M; Siev, E Daniel; Harris, B David; Berlin, H F; DiMattia, M; Sugimoto, D; Dugas, J; Benson, M; Stegemoller, R; Schmoll, M; Kinnaman, S; O'Connor, T; Powel, T; Rudolph, L; Lewiecki, M; Best, E; Chavez, J; Cohen, R; Colman, D; Ocampo, M; Heaney, L Vance; Rappley, G; Quezada, I; Santos, V; Nikfarjam, A; Reyes, M; Rodriguez, R Bardinas; Josephs, L S; Hernandez, R; Flores, P; Espinoza, L; Mejia, W; Pedraza, Z; Castaneda, R; Laguerre, J; Cook, R B; Patel, R P; Werner, H R; Blank, R C; Small, S H; Andersen, James; Holmes, D; Farmer, M; Wiener, Vikki; Pharr, W; Bray, B; Beekman, J; Andrawis, N; Gabra, N; Moche, T; Marty, Susan; Galvez, O; Kishore, P; Reyes, R; Garcia, R K; Lerma, G De Jesus; Pliquin, B; Mayfield, R; Durham, Nancy; Phillips, R; Baran, A; Kondo, N; Dempsey, S, Jr; Kufs, W; Laddis, T; Zimmer, K; Van DePol, M; Dweck, L; Kestler, M; Werner, N; Ashraf, M J; Schallert, G; Sligh, T; Trueba, P; Batista, J V; Trueba, P F; Martinez, T; Moya, J; Amarales, V; Santos, E Elizalde; Torres, P A; Diaz, T Lopez; Diaz, J A; Hodish, I; Else, T; Buras, E; Moratis, A; Valika, S; Rahman, A; Malalis, W; Box, E Jane Herron; Box, P; Kerwood, B; Nagaeva, J; Metz, C; Hinnant, J; Griswell, D; Philbeck, A; Dukkipati, R; Shaarawy, R; Patak, R; Kaye, W; Steinsapir, J; Horowitz, B; Denenberg, M; Reynolds, Caroline B; Jenkinsdr, M; Adlakha, A; Hicklin, Hy; Peelman, J; Lerman, S; Lamkin, S D; Smith, S; Gould, G; Cheung, D; Stephen, Z; Leigh, T; Norwood, P; Chelsea, F; Trejo, R; Neolms, K; Bache, R; Dinnerstein, A J; Sachson, R; Aronoff, S; Mendez, A; Brooks, S; Jones, L; Martinez, G; Dorfman, S; Schill, J; Leuck; Miklius, A; Maw, K; Andersen, J; Hahn, J; Gamarra, L; Buynak, R; Smith, M; Ames, J; Volom, P; Anderson, R; Desouza, C V; Shivaswamy, V; Lefebvre, G; Schweppe, L; Berenguer, R; Nelson, R; Mas, L; Gonzalez, N; Palacio, J M; Bartkowiak, A; Dilling, J L; Jordan, T L; Geishauser, J A; Jordan, R; Arias, E J; Griffin, C; Fisher, M A; Bryant, C A; Schnitz, W M; Kipgen, W; Ramos, C; Kasper, J; Lopez, R; Wright, E; Thomas, J; Weinstein, D; Emerick, G J; Mendelson, R; Aqua, K; Lafaille, J; Seco, G; Garcia, G; Cubillas, M; de Souza, J; Schneider, A; Tjaden, J; Goswami, G; Schubart, U; Bravo, W; Guerrero, J; Bertoli-Avella, M; Reyes, C; Dominguez, M; Ramos, S; Columbie, A; Ares-Romero, P A; Hechavarria, J; Villaverde, M; Doyle, N; Sherrod, T; Krishnaswamy, K; Aamir, S; Giddaluri, P; Guevara, S; Kazmi, P; Thomas, P; Popeil, L; Albright, D A; Pimentel, S; Mould, E; Cox, M; Alderson, T; Conrow, J; Sandberg, J; Raam, S; Suresh, B; Lafave, J; Lorenz, T; Johnston, J; Fereidouni, S S; Mahadevan, A; West, R F; Nelson, A Dominic; Scott, K; Ansari, S; Khan, B; Rastogi, A; Saumell, F; Gonzalez, G; Torres, E; Elias, R B Rodriguez; Hart, T; Gudavilla, G; Suarez, J; Savin, V; Khan, A; Wiegmann, T; Goel, A; Gomes, M; Fernandez-Gonzalez, M; Gustavo, F; Ivan, C; Chiong, R; Llerena, S N; Jimenez, M A; Oram, D; George, D; Lewis, J; Kiefer, J; Dollman, A; Edje, L; Fernandez, M; Pastor, F; Kandath, D; Lorch, D; Graves, A; Powell, R; Hooker, T; Shah, S; Gomez, N; Miranda, F; Rosales, J; Bayona, I; Gomez, Y; Rodriguez, J; Guedes, R; Rodriguez, Y; Wahlen, J; Jonathan, W; Spencer, H; Michael, W; Kumar, U; Govindariju, Kanakadurga; Ordonez, Sandra; Aguirre, Heather; Sulur, Paulgun; Agarwal, Nikhil; Peters, L; Kaviani, B; Fomenko, O; Firek, A; Loreen, W; Ronald, F; Olha, F; Parrillo, J; Janovitz, R Henry; Hutchinson, R; Delgado, E F; Ashley, A; Barbel-Johnson, K; Timothy, L; William, C; Al-Karadsheh, A; Hooper, L M; Perez, D; Guerrero, V; Tung, D; Loo, C; Sodolak, K; Michaelis, C; Jackson, R; Covington, D; Wise, J; Tran, T Huy Vu; Messina, T; Torres, D T; Falcone, J; Barettella, M; Patel, K; Ribo, A; Mattews, T; Amendolare, D; McGeehan, J N; Corder, C; Black, C S; Hearne, S; Bounds, C; Cinderella, J; Etherton, J; Kiem, S; Treuth, M; Burke, B; Tivikaran, V; Howard, S; Miller, C; Neff, H; Giullian, Jeffrey; McRae, J; Surratt, D; Phillips, J; Kretchmar, J; Valdes, M; Cruz, J A; Navarro, E; Garcia, R; Zewail, A; Tai-Chi-Kwo; Stevens, J; Diane, S; Kim, T; Gregory, L; Neal, S; William, S; Sangrigoli, R; Gejer, E; Stoller, S; Jeffrey, D; Colar, S; Kenneth, W; Farris, N; Mooney, S; Jamal, A; Nitin, B; Syed, R; Andrew, Y; Christopher, W; Abid, R; Claudio, G; Mojtaba, M; Amna, R; Michael, B; Vincent, T; Cherlin, R; Ashton, R; Pudi, K; Julian, W; Stephen, K; Ronald, A; Frias, J; Kelly, S; Hsia, S; Clemens, P; Farley, B; Raible, L H; Oliveros, O; Hafeez, H; Pecci, P; Bagga-Malhotra, S; Reza, R; Jamal, M Ahsen; Mulgado, M; Guevara, A; Vela, M; Ochoa, H; Melliza, T; Pena, G; Awua-Larbi, S; Shafi, M; Alausa, T; Polster, S; Earl, J; McNeill, R; Farrington, C; Carr, K; Nabat, M; Matthew, S; Yvette, E; Handelsman, Y; Delkhah, S; Ismail, Y; Janna, C; Akhtar, A; Neiman, A; Blumenthal, S; Colleen, V; Schmidt, D; Ashraf, E-M; Bhargava, A; Khoo, T; Langel, C; Theuma, P; Wright, D; Fitzgerald, K; Hitchcock, J; Capasso-Gulve, E; Wolff, E; Umpierrez, G; Priyathama, V; Francisco, P; Dawn, S; Quraishi, A; Kahn, B Howard; Ferro, F J; Hertz, B Bondy; Phelps, J E; Campbell, A; Downing, J-M; Pangtay, D; Pangatay, S; Villagran-Solis, K; Haseeb, M; Rettig, K; Kwan, R; Cox, R; Slimak, V; So, A; Schmedtje, J; Chang, A; Douglas, Z; McGarity, W; Jestel, J; Kanade, P; Julie, J; Asher, R; Canaan, Y; Perez, A; Alonso, I; Cutchin, R; Koser, A; Adeola, Y; Brito, S; Stocks, J; Frandsen, B; Weigelt, M; Stehouwer, E; Ince, C; Stephen, P; Shadi, B; Jeffrey, C; Thethi, T; Carpio, G R A; McDuffie, R H; Moreau, C S; Katalenich, B; McKendall-Lewis, C; Htun, W; Conroy, K; Lovre, D; Galagan, R; Olmeda, C Carrion; Sihota, A; Barton, A; Beasley, R; Nankivel, P; Aberle, M; Machin, I; Porras, J; Rodriguez, D; Albornoz, A; Haidar, A; Lopez-Santini, R H; Rivero, G F; Robins, G; Colyar, L A; Hutchins, C R; Sturm, D L; Hart, K A; Phillips, T Keith; Montgomery, C D; Taylor, P J; Albrecht, W; Fehlis, K; Lee, J; Overman, D; Box, M; Villarreal-Martinez, D; David-Svatek, D; Ajani, D; Shaikh, Z; Wheeler, K; Brown, M; Ghosh, C Sekhar; Bandukwala, I; Kleber, S; Madden, J; Bishara, M; Perry, K; Paoli-Bruno, J; Abreu, E; Espiritu, R; Zmeili, O; Christensen, T; Grubb, S D; Beloff, S; Caugh, A R; van Dijk, C; Yalavarthy, R; DeGraauw, J; Fabian, S; Gillum, D; Corrigan, G; Singh, H; Jensen, K; DeMore, S; Montague, T; Zieve, F; Levy, J R; Fredrickson, S K; Tarkington, P E; Patel, R; Chapla, P; Salacata, A; Walls, U; Iyer, R; Nguyen, K; Lettman, J; Appleman, B; Safavie, F; Scaliem, L; Eder, F; Maklad, S A; Schlaen, B Roxana; Molstead, J L; Hartwell, J A; Hubish, D Ann; Little, R Daniel; Rando, K Maria; Kelly, R L; Drury, M S; Young, P Si-Hai; Wininger, S J; Harman, A; Daza, R; Reyes, C R; Robbin, S; Sanchez, M; Rivera, I; Martinez, L; Garcia-Estrada, M; Iglesias, N; Dobs, A; Andrade, A; Falkowski, S; Parrott, T; Koon, A; Wood, T; Burkett, E; Chavous, K; Gupta, A; Estes, C; Loud, D; Rhodes, S; Chen, M; Bromley, L; Palma, R; Kattan, D; Kirk, U; Tatu, H; Stamatin, R; Lupea, S; Frasie, M; Colfer, H; Kane, L; Teklinski, A; Gadowski, G; Levanovich, P; Saba, F; Confident, L; Hossain, S; Steinberg, B; Philippe, B; Choroenthkongtrakal, S; Boccalano, F; Anand, R; Syam, V; Manohar, A; Suresh, P; Madhusudhan, P; Patel, P; Cambier, P; Klonaris, J; Cheng, W; Fisher, S R; Schelle, M E; Reese, L M; McLean, S L; Poock, J; Hoens, J; Rosie, A; Welshons, R; Dean, J; Kuhlman, P D; Luke, R A; Lohrbauer, L; Cunningham, M S; Buday, P; Lehmann, M; Chrzanowski, K; Fletcher, A; Hargrove, J; Harris, F; Debs-Perez, G; Maiquez, A; Cordoves, L; Georgescu, M; Tayoun, H; Perez, J; Hamzeh, I; Misra, A; Zhang, L; Forgosh, L; Loria, K; Roncari, C; Hommerding, J; Morris, G; Lebron, C; Blake, K; LaVenture, K; Lange, C; Levinson, L; Baungarten, T; Edevante, S; Shawley, S; Moyer, H; Elliott, K; Iachini, K; Rajan, R; Davis, C J; Shattuck, A M; Simon, W; Lakin, G F; Secrist, N B; Buth, D; Steere, D M; Talbot, K; Singh, N; Mascolo, R; Sloan, S B; Kmetzo, J J; Brown, J; Carter, L; Lawrence, M; Arauz-Pacheco, C; Lender, D; Kozlow, W; Cavanaugh, L; Wilson, J; Gujja, P; Akhter, F; Khan, M; Mohammed, A; Satyavolu, S; Ashraf, M; Dev, D; Yalamanchili, H B; Sumeyye, C I; Fernandes, H; Chaleff, F Myles; Jancko, M J; Trenche, S Mujica; Kaplan, W; Wilcox, S; Goisse, M; Rua, M David; Black, J; Chapman, K; Suh, D; Yan, L; Song, D; Chanara, S; Houchin, V; McKeinness, A; Sotolongo, R; Gutierrez, K; Miranda-Palma, B; Solano, M del Pilar; Jain, M; Needell, J; Banerjee, A; Jarratt, M; Hantel, Stefan; Lees, Kennedy R; Welty, Francine K; Freedman, Steven; Parhofer, Klaus G; Birkeland, Kare I; McGill, Janet; Tijssen, Jan G P; Clemmensen, Peter; Pehrson, Steen; Grande, Peer; Januzzi, James, Jr; Wood, Malissa J; Petrie, Mark; Sairanen, Tiina; Tatlisumak, Turgut; Soinne, Lauri; Kase, Carlos; Turan, Tanya; Mann, Johannes; Agarwal, Rajiv; Fogarty, Damian; Navaneethan, Sankar; Srinivas, Titte; Forsmark, Christopher; Frossard, Jean-Louis; Gelrud, Andres; Mayerle, Julia; Lee, Richard J; Heist, Rebecca; Sullivan, Ryan J; Buchbinder, Elizabeth I; Chodak, Gerald; Edelman, Martin J; Thompson, Vivian; Coles, Adrian

Afiliacions

Resum

Background: Individuals with type 2 diabetes mellitus are at increased risk for heart failure (HF), particularly those with coexisting atherosclerotic cardiovascular disease and/or kidney disease. Some but not all dipeptidyl peptidase-4 inhibitors have been associated with increased HF risk. We performed secondary analyses of HF and related outcomes with the dipeptidyl peptidase-4 inhibitor linagliptin versus placebo in CARMELINA (The Cardiovascular and Renal Microvascular Outcome Study With Linagliptin), a cardiovascular outcomes trial that enrolled participants with type 2 diabetes mellitus and atherosclerotic cardiovascular disease and/or kidney disease. Methods: Participants in 27 countries with type 2 diabetes mellitus and concomitant atherosclerotic cardiovascular disease and/or kidney disease were randomized 1:1 to receive once daily oral linagliptin 5 mg or placebo, on top of standard of care. All hospitalization for HF (hHF), cardiovascular outcomes, and deaths were prospectively captured and centrally adjudicated. In prespecified and post hoc analyses of HF and related events, Cox proportional hazards models adjusting for region and baseline history of HF were used. Recurrent hHF events were analyzed using a negative binomial model. In a subset of participants with left ventricular ejection fraction captured within the year before randomization, HF-related outcomes were assessed in subgroups stratified by left ventricular ejection fraction > or 50%. Results: CARMELINA enrolled 6979 participants (mean age, 65.9 years; estimated glomerular filtration rate, mL/min per 1.73m(2); hemoglobin A1c, 8.0%; 62.9% men; diabetes mellitus duration, 14.8 years), including 1873 (26.8%) with a history of HF at baseline. Median follow-up was 2.2 years. Linagliptin versus placebo did not affect the incidence of hHF (209/3494 [6.0%] versus 226/3485 [6.5%], respectively; hazard ratio [HR], 0.90; 95% CI, 0.74-1.08), the composite of cardiovascular death/hHF (HR, 0.94; 95% CI, 0.82-1.08), or risk for recurrent hHF events (326 versus 359 events, respectively; rate ratio, 0.94; 95% CI, 0.75-1.20). There was no heterogeneity of linagliptin effects on hHF by history of HF at baseline, baseline estimated glomerular filtration rate or urine albumin-creatinine ratio, or prerandomization left ventricular ejection fraction. Conclusions: In a large, international cardiovascular outcome trial in participants with type 2 diabetes mellitus and concomitant atherosclerotic cardiovascular disease and/or kidney disease, linagliptin did not affect the risk of hHF or other selected HF-related outcomes, including among participants with and without a history of HF, across the spectrum of kidney disease, and independent of previous left ventricular ejection fraction. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01897532.

Paraules clau