{rfName}
MY

License and use

Icono OpenAccess

Altmetrics

Analysis of institutional authors

Carrasco Gata, DavidAuthorArroyo Garcia, Rosa AdelaAuthorCarrasco DAuthor

Share

December 18, 2023
Publications
>
Article

MYB24 orchestrates terpene and flavonol metabolism as light responses to anthocyanin depletion in variegated grape berries

Publicated to:Plant Cell. 35 (12): 4238-4265 - 2023-11-30 35(12), DOI: 10.1093/plcell/koad228

Authors: Zhang, C; Dai, ZW; Ferrier, T; Orduna, L; Santiago, A; Peris, A; Wong, DCJ; Kappel, C; Savoi, S; Loyola, R; Amato, A; Kozak, B; Li, MM; Liang, AK; Carrasco, D; Meyer-Regueiro, C; Espinoza, C; Hilbert, G; Figueroa-Balderas, R; Cantu, D; Arroyo-Garcia, R; Arce-Johnson, P; Claudel, P; Errandonea, D; Rodríguez-Concepción, M; Duchêne, E; Huang, SSC; Castellarin, SD; Tornielli, GB; Barrieu, F; Matus, JT

Affiliations

ANU Research School of Biology - Author
Australian Natl Univ, Res Sch Biol, Ecol & Evolut, Canberra, ACT 2601, Australia - Author
Chinese Acad Sci, Inst Bot, Beijing Key Lab Grape Sci & Enol, Beijing 100093, Peoples R China - Author
Chinese Acad Sci, Inst Bot, Key Lab Plant Resources, Beijing 100093, Peoples R China - Author
CSIC - Instituto de Biologia Molecular y Celular de Plantas Primo Yufera - Author
Ecophysiologie et Génomique Fonctionnelle de la Vigne - Author
Institute of Botany, Chinese Academy of Sciences - Author
New York University - Author
NYU, Ctr Genom & Syst Biol, Dept Biol, New York, NY 10003 USA - Author
Pontificia Univ Catolica Chile, Dept Genet Mol & Microbiol, Santiago 8331150, Chile - Author
Pontificia Universidad Católica de Chile - Author
The University of British Columbia - Author
Univ Autonoma Chile, Fac Ciencias Salud, Inst Ciencias Biomed, Santiago 8910060, Chile - Author
Univ Autonoma Chile, Fac Ingn, Inst Ciencias Quim Aplicadas, Providencia, Chile - Author
Univ Bordeaux, Bordeaux Sci Agro, INRAE, EGFV,ISVV, 210 Chemin Leysotte, Villenave Dornon, France - Author
Univ British Columbia, Wine Res Ctr, Vancouver, BC V1V 1V7, Canada - Author
Univ Calif Davis, Dept Viticulture & Enol, Davis, CA 95616 USA - Author
Univ Politecn Madrid, Ctr Plant Biotechnol & Genom CBGP, INIA, Madrid 28223, Spain - Author
Univ Politecn Valencia, Inst Plant Mol & Cell Biol IBMCP, CSIC, Valencia, Spain - Author
Univ Potsdam, Inst Biochem & Biol, CSIC, D-14476 Potsdam, Germany - Author
Univ Strasbourg, SVQV, INRAE, F-68000 Colmar, France - Author
Univ Turin, Dept Agr Forest & Food Sci, I-10124 Turin, Italy - Author
Univ Valencia, Dept Fis Aplicada, ICMUV MALTA Consolider Team, Valencia 46100, Spain - Author
Univ Valencia, Inst Integrat Syst Biol I2SysBio, CSIC, Valencia 46980, Spain - Author
Univ Verona, Dept Biotechnol, I-37134 Verona, Italy - Author
Universidad Autónoma de Chile - Author
Universidad Politécnica de Madrid - Author
Università degli Studi di Torino - Author
Università degli Studi di Verona - Author
Universitat de València - Author
Universität Potsdam - Author
Université de Strasbourg - Author
University of California, Davis - Author
See more

Abstract

Variegation is a rare type of mosaicism not fully studied in plants, especially fruits. We examined red and white sections of grape (Vitis vinifera cv. 'Béquignol') variegated berries and found that accumulation of products from branches of the phenylpropanoid and isoprenoid pathways showed an opposite tendency. Light-responsive flavonol and monoterpene levels increased in anthocyanin-depleted areas in correlation with increasing MYB24 expression. Cistrome analysis suggested that MYB24 binds to the promoters of 22 terpene synthase (TPS) genes, as well as 32 photosynthesis/light-related genes, including carotenoid pathway members, the flavonol regulator HY5 HOMOLOGUE (HYH), and other radiation response genes. Indeed, TPS35, TPS09, the carotenoid isomerase gene CRTISO2, and HYH were activated in the presence of MYB24 and MYC2. We suggest that MYB24 modulates ultraviolet and high-intensity visible light stress responses that include terpene and flavonol synthesis and potentially affects carotenoids. The MYB24 regulatory network is developmentally triggered after the onset of berry ripening, while the absence of anthocyanin sunscreens accelerates its activation, likely in a dose-dependent manner due to increased radiation exposure. Anthocyanins and flavonols in variegated berry skins act as effective sunscreens but for different wavelength ranges. The expression patterns of stress marker genes in red and white sections of 'Béquignol' berries strongly suggest that MYB24 promotes light stress amelioration but only partly succeeds during late ripening.

Keywords

biosynthesiscolorexpressionmonoterpenepathwaysprofilesskinsynthase genestranscriptionAnthocyaninsCarotenoidsFlavonolsFruitFunctional-characterizationGene expression regulation, plantSunscreening agentsTerpenesVitis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Plant Cell due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 6/265, thus managing to position itself as a Q1 (Primer Cuartil), in the category Plant Sciences. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.88. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 4.81 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 13.22 (source consulted: Dimensions Oct 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-10-23, the following number of citations:

  • WoS: 19
  • Scopus: 25

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-10-23:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 34.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 35 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 40.45.
  • The number of mentions on the social network Facebook: 2 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 55 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Australia; Canada; Chile; China; France; Germany; Italy; Malt; United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (CARRASCO GATA, DAVID) .