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Grant support

This study was funded by the Spanish Ministry of Economy and Competitiveness (PSI2015-68793-C3-1-R and RTI2018-098762-B-C31), by Instituto de Salud Carlos III (ISCIII) through the project "PI20/00937" and co-funded by the European Union; the GAIN, Axencia Galega de Innovacion, IN607B2021/12 co-funded by the European Union, and Programa INVESTIGO, TR349V-2022-10000052-00 cofunded by the European Union. Complimentary, it was supported by predoctoral grants by the Spanish Ministry of Universities (FPU18/05768 and FPU18/00517) to AN and MCG, respectively, and (PRE2019-087612) to AGC; as well as a postdoctoral fellowship by the Spanish Ministry of Science and Innovation (FJC2020-046183-I) to JdFL.

Analysis of institutional authors

García-Colomo, AlejandraCorresponding AuthorCarrasco-Gomez, MartinCorresponding AuthorBruna, RicardoAuthor

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September 29, 2024
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Longitudinal changes in the functional connectivity of individuals at risk of Alzheimer's disease

Publicated to:Geroscience. 46 (3): 2989-3003 - 2024-06-01 46(3), DOI: 10.1007/s11357-023-01036-5

Authors: García-Colomo, A; Nebreda, A; Carrasco-Gómez, M; de Frutos-Lucas, J; Ramirez-Toraño, F; Spuch, C; Comis-Tuche, M; Bruña, R; Alfonsín, S; Maestú, F

Affiliations

Hosp Clin San Carlos IdISSC, Hlth Res Inst, Madrid 28240, Spain - Author
SERGAS UVIGO, Galicia Hlth Res Inst IIS Galicia, Translat Neurosci Res Grp, CIBERSAM, Vigo, Spain - Author
Univ Complutense Madrid, Ctr Cognit & Computat Neurosci, Madrid 28223, Spain - Author
Univ Complutense Madrid, Dept Expt Psychol Cognit Psychol & Speech Languag, Madrid 28223, Spain - Author
Univ Complutense Madrid, Dept Radiol, Madrid 28240, Spain - Author
Univ Politecn Madrid, Dept Elect Engn, Madrid 28040, Spain - Author
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Abstract

First-degree relatives of Alzheimer's disease patients constitute a key population in the search for early markers. Our group identified functional connectivity differences between cognitively unimpaired individuals with and without a family history. In this unprecedented follow-up study, we examine whether family history is associated with a longitudinal increase in the functional connectivity of those regions. Moreover, this is the first work to correlate electrophysiological measures with plasma p-tau231 levels, a known pathology marker, to interpret the nature of the change. We evaluated 69 cognitively unimpaired individuals with a family history of Alzheimer's disease and 28 without, at two different time points, approximately 3 years apart, including resting state magnetoencephalography recordings and plasma p-tau231 determinations. Functional connectivity changes in both precunei and left anterior cingulate cortex in the high-alpha band were studied using non-parametric cluster-based permutation tests. Connectivity values were correlated with p-tau231 levels. Three clusters emerged in individuals with family history, exhibiting a longitudinal increase of connectivity. Notably, the clusters for both precunei bore a striking resemblance to those found in previous cross-sectional studies. The connectivity values at follow-up and the change in connectivity in the left precuneus cluster showed significant positive correlations with p-tau231. This study consolidates the use of electrophysiology, in combination with plasma biomarkers, to monitor healthy individuals at risk of Alzheimer's disease and emphasizes the value of combining noninvasive markers to understand the underlying mechanisms and track disease progression. This could facilitate the design of more effective intervention strategies and accurate progression assessment tools.

Keywords

Alzheimer diseaseAlzheimer's disease riskAlzheimer’s disease riskAmyloid-betaDiagnosiDiagnosisDisruptionFollow-up studiesFunctional connectivityHumansHypersynchronizationLongitudinalMagnetic resonance imagingMagnetoencephalographyMeMegMild cognitive impairmentP-tau231P-tau231, megTau

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Geroscience due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 9/74, thus managing to position itself as a Q1 (Primer Cuartil), in the category Geriatrics & Gerontology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-05:

  • WoS: 3
  • Scopus: 5

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 12.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 15 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 22.75.
  • The number of mentions on the social network X (formerly Twitter): 8 (Altmetric).
  • The number of mentions in news outlets: 2 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (GARCIA VERGNOLLE, LUCIA) .

the authors responsible for correspondence tasks have been GARCIA VERGNOLLE, LUCIA and CARRASCO GOMEZ, MARTIN.