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Analysis of institutional authors

De Sousa B.f.s.Author

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October 31, 2024
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Development, characterization and evaluation of in vitro safety and in vivo efficacy of repellent gel formulations

Publicated to:Journal Of Drug Delivery Science And Technology. 101 106297-106297 - 2024-11-01 101(), DOI: 10.1016/j.jddst.2024.106297

Authors: da Silva MRM; Castellane TCL; de Sousa BFS; Lemos EGdM; dos Santos EP; Oliveira CA; Ricci-Junior E

Affiliations

Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro - Author
Universidade Estadual Paulista "Júlio de Mesquita Filho" - Author
Universidade Estadual Paulista "Júlio de Mesquita Filho"; Universidad Politécnica de Madrid - Author
Universidade Federal do Rio de Janeiro - Author
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Abstract

Contagious diseases caused by mosquito bites are responsible for epidemic outbreaks around the world. Applying mosquito repellents is the main and most cost-effective prophylactic measure to reduce the transmission risk of arboviruses. In this study, two topical gel Formulations were developed as mosquito repellents which use two different systems to release 20 % Icaridin. The first, Formulation 1b uses Pluronic F127®, and the second, Formulation 2b uses a biopolymer produced by bacteria from the Rhizobium tropici species. The repellent Formulations developed showed non-Newtonian behavior. For Formulation 1b the viscosity increased after adding Icaridin. However, for Formulation 2b, there was no increase in viscosity after adding the active substance. The thixotropy analysis showed that the Formulations have good recovery of their structure and adhesion. Adding of Icaridin led to an increase in gel strength in Formulation 1b and did not change the gel strength for Formulation 2b. The Formulations presented very similar occlusion capacities which were all higher than free Icaridin. The Formulations were not cytotoxic in the concentration range between 0.04 % and 0.3 %. In addition, at the 0.62 % concentration, they showed a slight reduction in cell viability, although the LD50 value was not reached. The mean protection time was longer for Formulation 2b compared to Formulation 1b. Both Formulations had a longer mean protection time than free Icaridin against Aedes aegypti. The combination of Icaridin with Pluronic F127® and the biopolymer is an innovation in the pharmaceutical area.

Keywords

Astronomia / físicaBiotecnologíaCiências biológicas iCiências biológicas iiEngenharias iEngenharias iiFarmaciaGeografíaInterdisciplinarMateriaisMedicina iMedicina iiPharmaceutical sciencePharmacology & pharmacyQuímica

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Drug Delivery Science And Technology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 48/352, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-10-12:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 4 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    Leadership analysis of institutional authors

    This work has been carried out with international collaboration, specifically with researchers from: Brazil.