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Rodríguez-Casillas L.Author

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June 9, 2025
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Diurnal control of H3K27me1 deposition shapes expression of a subset of cell cycle and DNA damage response genes

Publicated to:Plant Journal. 120 (6): 2325-2336 - 2024-01-01 120(6), DOI: 10.1111/tpj.17114

Authors: Fung-Uceda J; Gómez MS; Rodríguez-Casillas L; González-Gil A; Gutierrez C

Affiliations

Centro de Biologia Molecular Severo Ochoa; CSIC-UAM; Nicolas Cabrera 1; Cantoblanco; Madrid; 28049; Spain - Author

Abstract

Rhythmic oscillation of biological processes helps organisms adapt their physiological responses to the most appropriate time of the day. Chromatin remodeling has been described as one of the molecular mechanisms controlling these oscillations. The importance of these changes in transcriptional activation as well as in the maintenance of heterochromatic regions has been widely demonstrated. However, little is still known on how diurnal changes can impact the global status of chromatin modifications and, hence, control gene expression. In plants, the repressive mark H3K27me1, deposited by ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 and 6 (ATXR5 and 6) methyltransferases, is largely associated with transposable elements but also covers lowly expressed genes. Here we show that this histone modification is preferentially deposited during the night. In euchromatic regions, it is found along the bodies of DNA damage response genes (DDR), where it is needed for their proper expression. The absence of H3K27me1 translates into an enhanced expression of DDR genes that follows a rhythmic oscillation pattern. This evidences a link between chromatin modifications and their synchronization with the diurnal cycle in order to accurately modulate the activation of biological processes to the most appropriate time of the day. © 2024 The Author(s). The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd.

Keywords

ActivationArabidopsisArabidopsis proteinArabidopsis proteinsAtxr5/6Cell cycleChromatinChromatin assembly and disassemblyCircadian rhythmControl systemsDamageDiurnal cycleDiurnal cyclesDna damageDna damage responseDna repairDna-repairEuchromatinFungiGene expressionGene expression regulationGene expression regulation, plantGenesGenes expressionGeneticsH3k27me1HistoneHistone lysine methyltransferaseHistone modificationHistone-lysine n-methyltransferaseHistonesMetabolismNucleic acidsOscillationPhysiological modelsPhysiologyPlant diseasesProcessesTranscription

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Plant Journal due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 24/273, thus managing to position itself as a Q1 (Primer Cuartil), in the category Plant Sciences. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-08-02:

  • Scopus: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 2.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 2 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 18.3.
  • The number of mentions on the social network X (formerly Twitter): 30 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.