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Analysis of institutional authors

Nobari, HadiAuthor

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December 17, 2025
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Effects of high and moderate intensity exercise training on sex hormones and testicular damage induced by cisplatin in rats

Publicated to: BMC Sports Science, Medicine and Rehabilitation. 17 (1): 361- - 2025-12-01 17(1), DOI: 10.1186/s13102-025-01379-w

Authors:

Parastesh, M; Ghahfarrokhi, MM; Bayatiani, MR; Abbasi, Y; Pooladi, M; Khalounejad, H; Nobari, H
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Affiliations

Arak Univ Med Sci, Fac Para Med, Dept Radiotherapy & Med Phys, Arak, Iran - Author
Arak Univ Med Sci, Sch Med, Dept Anat, Arak, Iran - Author
Arak Univ, Fac Sports Sci, Dept Sports Physiol, Arak 38156879, Iran - Author
Arak Univ, Res Inst Appl Studies Sports Sci, Arak, Iran - Author
Khansari Hosp, Arak, Iran - Author
Univ Politecn Madrid, Fac Phys Act & Sport Sci INEF, Dept Hlth & Human Performance, LFE Res Grp, Madrid, Spain - Author
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Abstract

Background Cisplatin, a potent chemotherapeutic agent, induces oxidative stress, inflammation, and apoptosis in the testes, reduces sex hormones (testosterone, LH, FSH), and impairs sperm quality and structure. MICT typically increases testicular function and hormone levels, whereas HIIT may negatively affect steroidogenesis and the HPG axis, although findings vary. This study investigates the effects of HIIT and MICT on reducing cisplatin-induced testicular damage in rat, providing a noninvasive approach to preserve fertility for chemotherapy patients. Methods In this randomized controlled experimental study twenty-four eight-week-old Sprague Dawley rats (200-240 g) were randomly assigned into four groups (n = 6 per group): healthy control (HC), cisplatin control (CC), Cisplatin-moderate intensity continuous training (C-MICT) and Cisplatin-high intensity interval training (C-HIIT). Except for the HC group, in other groups, 5 mg/kg of cisplatin was injected intraperitoneally as a single dose. HIIT involved alternating high-speed intervals (54 m/min, 30s) with recovery (40 m/min, 3 min), progressing to 20 intervals per session; MICT consisted of continuous running at 27 m/min for up to 60 min, both performed 6 days/week. Sex hormones, histological parameters of testicular tissue, sperm parameters and oxidant/lipid-peroxide were measured. Results Cisplatin injection caused a significant decrease in LH, FSH, and testosterone compared to the HC group (P
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Keywords

ApoptosisChemotherapyExercise trainingFertility hormonesOxidative stressPhysical-activityProtective roleSperm characteristicsSperm qualityTesticular tissueTestosteroneToxicityYoung

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal BMC Sports Science, Medicine and Rehabilitation due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 25/175, thus managing to position itself as a Q1 (Primer Cuartil), in the category Rehabilitation.

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 7.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 7 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Iran.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (NOBARI, HADI).

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Project objectives

La aportación persigue evaluar los efectos del entrenamiento de alta intensidad intermitente (HIIT) y de intensidad moderada continua (MICT) sobre el daño testicular inducido por cisplatino en ratas. Se propone analizar la influencia de ambos tipos de ejercicio en los niveles de hormonas sexuales (testosterona, LH, FSH) afectados por el tratamiento con cisplatino. Asimismo, se pretende determinar el impacto del ejercicio en parámetros histológicos del tejido testicular y en la calidad y estructura espermática. Otro objetivo es caracterizar los cambios en los marcadores de estrés oxidativo y peroxidación lipídica asociados a la toxicidad del cisplatino. Finalmente, se busca establecer un enfoque no invasivo para preservar la fertilidad en pacientes sometidos a quimioterapia.
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Most relevant results

Los resultados más relevantes del estudio evidencian que la administración de cisplatino indujo una disminución significativa de las hormonas sexuales LH, FSH y testosterona en comparación con el grupo control saludable (P < 0,05). El entrenamiento de intensidad moderada continua (MICT) mejoró significativamente los niveles hormonales y la calidad espermática, así como redujo el daño histológico testicular y el estrés oxidativo causado por cisplatino. Por otro lado, el entrenamiento interválico de alta intensidad (HIIT) no mostró mejoras comparables y podría afectar negativamente la esteroidogénesis y el eje hipotálamo-hipófiso-gonadal. Estos hallazgos sugieren que MICT es una intervención no invasiva eficaz para mitigar el daño testicular inducido por cisplatino en ratas.
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