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Grant support

This work was supported by grants from Ministerio de Economia y Competitividad (MINECO) of Spain, the European Regional Development Fund (ERDF) and FP7 Funds of the European Commission, BFU2013-41160-P, BFU2016-80315-P, and PCIG11-GA-2012-322082 to M.A.M.-R., AGL2012-33610 and BIO2015-64255-R to J.M.P.-P., and BIO2014-52091-R to J.C.P. M.A.M.-R. was supported by a Ramon y Cajal contract from MICINN.

Analysis of institutional authors

Bustillo-Avendano, EstefanoAuthorGude, InmaculadaAuthorPerianez-Rodriguez, JuanCorresponding AuthorCarlos Del Pozo, JuanAuthorAngel Moreno-Risueno, MiguelCorresponding Author

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Article

Regulation of Hormonal Control, Cell Reprogramming, and Patterning during De Novo Root Organogenesis

Publicated to:Plant Physiology. 176 (2): 1709-1727 - 2018-02-01 176(2), DOI: 10.1104/pp.17.00980

Authors: Bustillo-Avendano, Estefano; Ibanez, Sergio; Sanz, Oscar; Sousa Barros, Jessica Aline; Gude, Inmaculada; Perianez-Rodriguez, Juan; Micol, Jose Luis; Carlos Del Pozo, Juan; Angel Moreno-Risueno, Miguel; Manuel Perez-Perez, Jose;

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Abstract

Body regeneration through formation of new organs is a major question in developmental biology. We investigated de novo root formation using whole leaves of Arabidopsis (Arabidopsis thaliana). Our results show that local cytokinin biosynthesis and auxin biosynthesis in the leaf blade followed by auxin long-distance transport to the petiole leads to proliferation of J0121-marked xylem-associated tissues and others through signaling of INDOLE-3-ACETIC ACID INDUCIBLE28 (IAA28), CRANE (IAA18), WOODEN LEG, and ARABIDOPSIS RESPONSE REGULATORS1 (ARR1), ARR10, and ARR12. Vasculature proliferation also involves the cell cycle regulator KIP-RELATED PROTEIN2 and ABERRANT LATERAL ROOT FORMATION4, resulting in a mass of cells with rooting competence that resembles callus formation. Endogenous callus formation precedes specification of postembryonic root founder cells, from which roots are initiated through the activity of SHORT-ROOT, PLETHORA1 (PLT1), and PLT2. Primordia initiation is blocked in shr plt1 plt2 mutant. Stem cell regulators SCHIZORIZA, JACKDAW, BLUEJAY, and SCARECROW also participate in root initiation and are required to pattern the new organ, as mutants show disorganized and reduced number of layers and tissue initials resulting in reduced rooting. Our work provides an organ regeneration model through de novo root formation, stating key stages and the primary pathways involved.

Keywords

ArabidopsisArabidopsis-thalianaAuxin effluxCellular reprogrammingCytokininFate transitionGene expression regulation, developmentalGene expression regulation, plantIndoleacetic acidsLateral rootsModels, biologicalOf-function mutationPlantPlant growth regulatorsPlant leavesPlant rootsQuiescent centerRegenerationShootSignal transduction

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Plant Physiology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2018, it was in position 10/228, thus managing to position itself as a Q1 (Primer Cuartil), in the category Plant Sciences. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.93. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 4.25 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 11.06 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-02, the following number of citations:

  • WoS: 47
  • Scopus: 94
  • Google Scholar: 93
  • OpenCitations: 91

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 192.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 194 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 28.48.
  • The number of mentions on the social network Facebook: 3 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 34 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Brazil.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (BUSTILLO AVENDAÑO, ESTEFANO) .

the authors responsible for correspondence tasks have been Sanz, Oscar, Periañez Rodriguez, Juan and MORENO RISUEÑO, MIGUEL ANGEL.