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De Ansorena, ElisaAuthor

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February 21, 2022
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The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock

Publicated to: Acs Chemical Biology. 12 (6): 1466-1471 - 2017-06-01 12(6), DOI: 10.1021/acschembio.6b00978

Authors: de Montaigu, Amaury; Oeljeklaus, Julian; Krahn, Jan H.; Suliman, Mohamed N. S.; Halder, Vivek; de Ansorena, Elisa; Nickel, Sabrina; Schlicht, Markus; Plihal, Ondsiej; Kubiasova, Karolina; Radova, Lenka; Kracher, Barbara; Toth, Reka; Kaschani, Farnusch; Coupland, George; Kombrink, Erich; Kaiser, Markus;

Affiliations

Heinrich Heine Univ, Inst Quantitat Genet & Genom Plants, D-40225 Dusseldorf, Germany - Author
Masaryk Univ, Cent European Inst Technol, Ctr Mol Med, Kamenice 753-5, Brno 62500, Czech Republic - Author
Max Planck Inst Plant Breeding Res, Chem Biol Lab, Carl von Linne Weg 10, D-50829 Cologne, Germany - Author
Max Planck Inst Plant Breeding Res, Dept Dev Biol, Carl von Linne Weg 10, D-50829 Cologne, Germany - Author
Max Planck Inst Plant Breeding Res, Dept Plant Microbe Interact, Bioinformat, Carl von Linne Weg 10, D-50829 Cologne, Germany - Author
Palacky Univ, Ctr Reg Hana Biotechnol & Agr Res, Dept Mol Biol, Slechtitelu 241-27, Olomouc 78371, Czech Republic - Author
Univ Duisburg Essen, ZMB, Dept Biol Chem, Fac Biol, Univ Str 2, D-45117 Essen, Germany - Author
Univ Oxford, Dept Plant Sci, South Parks Rd, Oxford OX1 3RB, England - Author
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Abstract

Plant growth regulating properties of brevicompanines (Brvs), natural products of the fungus Penicillium brevicompactum, have been known for several years, but further investigations into the molecular mechanism of their bioactivity have not been performed. Following chemical synthesis of brevicompanine derivatives, we studied their activity in the model plant Arabidopsis by a combination of plant growth assays, transcriptional profiling, and numerous additional bioassays. These studies demonstrated that brevicompanines cause transcriptional misregulation of core components of the circadian clock, whereas other biological read-outs were not affected. Brevicompanines thus represent promising chemical tools for investigating the regulation of the plant circadian clock. In addition, our study also illustrates the potential of an unbiased -omics-based characterization of bioactive compounds for identifying the often cryptic modes of action of small molecules.

Keywords

Arabidopsis-thalianaAuxinChemical biologyExpressionGenesOpportunitiesSystemTime

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Acs Chemical Biology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2017, it was in position 57/293, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-12-06:

  • WoS: 5
  • Scopus: 6
  • Europe PMC: 4

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 30.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 30 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 14.
  • The number of mentions on the social network X (formerly Twitter): 11 (Altmetric).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Czech Republic; Germany; United Kingdom.

Awards linked to the item

Financial support for this work was provided by the European Research Council (starting grant no. 258413, M.K.), Czech Science Foundation grant (16-04184S, O.P.), and the Max Planck Society (E.K, US., and A.d.M). V.H. and M.N.S.S. are recipients of DAAD fellowships (A/10/74508 and A/11/ 92298, respectively).